AIDS Virus Proteins and Nonhuman Primate Facilities

Sarngadharan, Mangalas G.

Abstract

The major objectives of this contract are to obtain large quantities of purified gp120 and other viral antigens from human immunodeficiency virus (HIV-1). These viral aproteins will be utilized to study the immune response in non-human primates including chimpanzees and to determine whether the antibodies are type specific or group specific in virus neutralization assays.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Division of Cancer Epidemiology And Genetics (NCI)
• Type: Research and Development Contracts (N01)
• Project #: N01CP087214-003
• Application #: 3634526
• Project Start: 1988-03-01
• Project End: 1990-11-30
• Budget Start: 1988-12-01
• Budget End: 1989-11-30
• Fiscal Year: 1989

Institution

• Name: Advanced Bioscience Laboratories, Inc.
• City: Kensington
• State: MD
• Country: United States
• Zip Code: 20895

Publications

Pal, R; di Marzo Veronese, F; Nair, B C et al. (1992) Characterization of a neutralizing monoclonal antibody to the external glycoprotein of HIV-1. Intervirology 34:86-93

Pal, R; Mumbauer, S; Hoke, G M et al. (1991) Brefeldin A inhibits the processing and secretion of envelope glycoproteins of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 7:707-12

Stein, C A; Pal, R; DeVico, A L et al. (1991) Mode of action of 5'-linked cholesteryl phosphorothioate oligodeoxynucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitro. Biochemistry 30:2439-44

Pal, R; Mumbauer, S; Hoke, G et al. (1991) Effect of Evans blue and trypan blue on syncytia formation and infectivity of human immunodeficiency virus type I and type II in vitro. AIDS Res Hum Retroviruses 7:537-43

Pal, R; Nair, B C; Hoke, G M et al. (1991) Lateral diffusion of CD4 on the surface of a human neoplastic T-cell line probed with a fluorescent derivative of the envelope glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV-1). J Cell Physiol 147:326-32

Pal, R; Reitz Jr, M S; Tschachler, E et al. (1990) Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly. AIDS Res Hum Retroviruses 6:721-30