In this contract compounds will be obtained from the pharmaceutical industry, academic and Governmental laboratories. These compounds will be studied as potential pharmacotherapies for opiate abuse. Their abuse liability will be assessed as well. Test to be used include: antiociceptive assays in rodents, intraperitoneal infusion in rats, single dose abstinence suppression precipitated withdrawal in opiate-dependent non-human primates, physical dependence in naive non-human primates as well as self-administration and discrimination in primates. Compounds showing sufficient promise as pharmacotherapies will become candidates for clinical trial in human subjects. Abuse liability data developed by this contract are used to make decision as to scheduling of compounds under domestic as well as international drug control legislation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research and Development Contracts (N01)
Project #
N01DA038200-001
Application #
2306341
Study Section
Project Start
1993-09-28
Project End
1995-09-27
Budget Start
1994-06-13
Budget End
1995-06-27
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298