The purpose of this contract is to design and synthesize compounds which affect primarily dopaminergic systems and either substitute for cocaine or anatagoize its effects. The project shall involve the synthesis of any of the following: dopamine uptake inhibitors with a slower rate of onset than cocaine; compound which affect dopaminergic systems through the inhibition of dopamine or serotonin transporters; serotonin transporters; serotonin transporter selective cocaine analogs; dopamine partial agonists, and anatagonists; and dopamine sparing cocaine antagoists (Compounds that bind to the dopamine transporter without inhibiting uptake); and compound selective for D1 and D3 receptors. The project shall also provide for the scale-up production, and analog synthesis, of promissing compounds. The major goal of this project is to provide NIDA with a resource of novel compounds with potential use in the treatment of cocaine abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research and Development Contracts (N01)
Project #
N01DA078084-003
Application #
6070655
Study Section
Project Start
1997-09-29
Project End
2000-09-28
Budget Start
1999-03-29
Budget End
2000-09-28
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Southern Research Institute
Department
Type
DUNS #
006900526
City
Birmingham
State
AL
Country
United States
Zip Code
35205