The purpose of this contract is to identify inbred strains of mice with profound, early-onset, inherited hearing impairment, and to determine the chromosomal localization of the affected mouse gene in these strains.

Project Start
1996-06-17
Project End
2003-06-30
Budget Start
1999-10-06
Budget End
2000-06-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Odeh, Hana; Hunker, Kristina L; Belyantseva, Inna A et al. (2010) Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse. Am J Hum Genet 86:148-60
Karolyi, I Jill; Dootz, Gary A; Halsey, Karin et al. (2007) Dietary thyroid hormone replacement ameliorates hearing deficits in hypothyroid mice. Mamm Genome 18:596-608
Zheng, Q Y; Johnson, K R; Erway, L C (1999) Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130:94-107
Noben-Trauth, K; Zheng, Q Y; Johnson, K R et al. (1997) mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44:266-72