Develop a safe, effective, and otherwise attractive vaccine against dental caries for human use. Establish in a rat model the most effective caries-prevention combination of antigen, adjuvant, and dosing regimen using the gastric route of immunization. Crude S. mutans preparations and then purified S. mutans antigens will be tested with selected particulate adjuvants for effects on plasma and salivary immunoglobulins, oral S. mutans levels, and caries.

Project Start
1984-01-01
Project End
Budget Start
1987-04-01
Budget End
1987-08-31
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
School of Medicine & Dentistry
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294