To test chemicals . of interest to the NTP for their ability to cause chromosome damage in vitro, as measured by the induction of chromosome aberrations and sister chromatid exchanges, and in vivo, as measured by the induction of chromosome aberrations, sister chromatid exchanges, and micronuclei, in bone marrow cells of mice and rats. The results obtained from these tests will be used to assist in the evaluation of other in vivo toxicity test results, and will be compared with the responses of the same chemicals in other genetic test systems.

Project Start
1990-06-30
Project End
1995-06-29
Budget Start
1994-12-23
Budget End
1996-06-29
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Environmental Health Research & Testing
Department
Type
DUNS #
City
Lexington
State
KY
Country
United States
Zip Code
40503
Zeiger, E; Erexson, G; Mortelmans, K et al. (1997) Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine). Mutat Res 393:189-97