Develop Human Cell Assay Systems for Genetic Toxicity

Crespi, Charles L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Research and Development Contracts (N01)
• Project #: N01ES055093-000
• Application #: 3641167
• Project Start: 1985-05-01
• Project End: 1988-04-30
• Budget Start: 1985-05-01
• Budget End: 1986-04-30
• Fiscal Year: 1985

Institution

• Name: Gentest Corporation
• City: Woburn
• State: MA
• Country: United States

Publications

Crespi, C L; Seixas, G M; Turner, T et al. (1990) Sodium fluoride is a less efficient human cell mutagen at low concentrations. Environ Mol Mutagen 15:71-7

Davies, R L; Crespi, C L; Rudo, K et al. (1989) Development of a human cell line by selection and drug-metabolizing gene transfection with increased capacity to activate promutagens. Carcinogenesis 10:885-91

Crespi, C L; Langenbach, R; Rudo, K et al. (1989) Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays. Carcinogenesis 10:295-301

Crespi, C L; Seixas, G M; Penman, B W (1987) The induction of aneuploidy by nitrogen mustard in a human lymphoblastoid cell line. Mutat Res 190:69-76

Penman, B W; Crespi, C L (1987) Analysis of human lymphoblast mutation assays by using historical negative control data bases. Environ Mol Mutagen 10:35-60