Project Start
1985-09-30
Project End
1990-09-29
Budget Start
1987-05-12
Budget End
1988-09-29
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Arizona
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722
Parrish, A R; Gandolfi, A J; Brendel, K (1995) Precision-cut tissue slices: applications in pharmacology and toxicology. Life Sci 57:1887-901
Fisher, R L; Hasal, S J; Sipes, I G et al. (1995) Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fischer-344 and human liver slices. Hum Exp Toxicol 14:414-21
Wishnies, S M; Parrish, A R; Sipes, I G et al. (1991) Biotransformation activity in vitrified human liver slices. Cryobiology 28:216-26
Barr, J; Weir, A J; Brendel, K et al. (1991) Liver slices in dynamic organ culture. II. An in vitro cellular technique for the study of integrated drug metabolism using human tissue. Xenobiotica 21:341-50
Fisher, R; Barr, J; Zukoski, C F et al. (1991) In-vitro hepatotoxicity of three dichlorobenzene isomers in human liver slices. Hum Exp Toxicol 10:357-63
Fisher, R; Putnam, C W; Koep, L J et al. (1991) Cryopreservation of pig and human liver slices. Cryobiology 28:131-42
Smith, B J; Sipes, I G (1991) Epoxidation of 4-vinylcyclohexene by human hepatic microsomes. Toxicol Appl Pharmacol 109:367-71
Connors, S; Rankin, D R; Gandolfi, A J et al. (1990) Cocaine hepatotoxicity in cultured liver slices: a species comparison. Toxicology 61:171-83
Gunawardhana, L; Barr, J; Weir, A J et al. (1988) Liver slices: an in vitro system for determination of N-acetylation in human liver. Proc West Pharmacol Soc 31:137-41
Sipes, I G; Fisher, R L; Smith, P F et al. (1987) A dynamic liver culture system: a tool for studying chemical biotransformation and toxicity. Arch Toxicol Suppl 11:20-33