Abstract

The purpose of this contract is to obtain detailed chemical disposition data from approximately 5 studies of selected environmental contaminants or model compounds per year. A study consists of the determination of absorption, distribution, metabolism and excretion of a selected compound in a given species. Most studies will be conducted in Fischer 344 rats; however, some studies may be required in other species.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research and Development Contracts (N01)
Project #
N01ES065137-005
Application #
2310383
Study Section
Project Start
1986-06-30
Project End
1991-06-29
Budget Start
1991-05-01
Budget End
1991-06-29
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Research Triangle Institute
Department
Type
DUNS #
131606022
City
Research Triangle Park
State
NC
Country
United States
Zip Code
27709

  Publications

Mathews, J M; Parker, M K; Matthews, H B (1991) Metabolism and disposition of diethylene glycol in rat and dog. Drug Metab Dispos 19:1066-70
Mathews, J M; Troxler, P S; Jeffcoat, A R (1990) Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses. J Toxicol Environ Health 30:15-22