Prechronic and chronic toxicity studies of Isobutyl Nitrite using exposure by inhalation to F344/N rats and B6C3Fl mice of both sexes will be performed. These tests will characterize the toxicity associated with exposure (prechronic and chronic) to the chemical, including target organs, no-effect level, differences in sensitivity between sexes and species, and slope of the dose response curve.
| Ratajczak, H V; Thomas, P T; House, R V et al. (1995) Local versus systemic immunotoxicity of isobutyl nitrite following subchronic inhalation exposure of female B6C3F1 mice. Fundam Appl Toxicol 27:177-84 |
