One of the primary goals of this contract is to determine the developmental toxicity of chemicals to which a wide segment of the population is exposed, especially women of childbearing age, Since it is difficult to asses exposure potential to developmental toxicants and outcome of exposure within this group, well-controlled animal studies provide a basis for human risk assessment. For this purpose, most studies will be designed to determine a dose-response relationship in addition to the detection of a potential for developmental toxicity. This contract is comprised of three tasks: developmental toxicity range- finding studies (Task 1), FDA Segment 2 developmental toxicity testing (Task 2), and evaluation of newborn pups from reproductive toxicity test systems contract (N01-ES-15323) for developmental toxicity (Task 3). The AIDS Option will test AIDS therapy drag combinations for developmental toxicity (Task 2). This contract will provide a resource to test NTP nominated chemicals and continue to improve testing systems in reproductive and development toxicology.

Project Start
1996-09-30
Project End
2001-09-29
Budget Start
1998-07-13
Budget End
1999-09-29
Support Year
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Research Triangle Institute
Department
Type
DUNS #
131606022
City
Research Triangle Park
State
NC
Country
United States
Zip Code
27709
Price, Catherine J; George, Julia D; Marr, Melissa C et al. (2006) Prenatal developmental toxicity evaluation of 2',3'-dideoxyinosine (ddI) and 2',3'-didehydro-3'-deoxythymidine (d4T) co-administered to Swiss Albino (CD-1) mice. Birth Defects Res B Dev Reprod Toxicol 77:207-15
Jahnke, Gloria D; Price, Catherine J; Marr, Melissa C et al. (2006) Developmental toxicity evaluation of berberine in rats and mice. Birth Defects Res B Dev Reprod Toxicol 77:195-206
Price, Catherine J; Marr, Melissa C; Myers, Christina B et al. (2005) Postnatal development of rat pups after maternal exposure to diethanolamine. Birth Defects Res B Dev Reprod Toxicol 74:243-54
Jahnke, Gloria D; Price, Catherine J; Marr, Melissa C et al. (2004) Developmental toxicity evaluation of emodin in rats and mice. Birth Defects Res B Dev Reprod Toxicol 71:89-101
Tyl, R W; Price, C J; Marr, M C et al. (2003) Developmental toxicity evaluation of sodium thioglycolate administered topically to Sprague-Dawley (CD) rats and New Zealand White rabbits. Birth Defects Res B Dev Reprod Toxicol 68:144-61
George, Julia D; Price, Catherine J; Marr, Melissa C et al. (2002) Evaluation of the developmental toxicity of formamide in New Zealand white rabbits. Toxicol Sci 69:165-74
George, J D; Price, C J; Marr, M C et al. (2001) Evaluation of the developmental toxicity of isoeugenol in Sprague-Dawley (CD) rats. Toxicol Sci 60:112-20
George, J D; Price, C J; Marr, M C et al. (2001) Developmental toxicity evaluation of 1,2,3,4-butanetetracarboxylic acid in Sprague Dawley (CD) rats. Reprod Toxicol 15:413-20
George, J D; Price, C J; Marr, M C et al. (2000) Evaluation of the developmental toxicity of formamide in Sprague-Dawley (CD) rats. Toxicol Sci 57:284-91
Jahnke, G; Marr, M; Myers, C et al. (1999) Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicol Sci 50:271-9