1. The Contractor shall test environmental chemicals in laboratory animals (in particular, mice or rats, or rabbits), and develop data on the general and reproductive toxicity of such chemicals. 2. There are two kinds of work involved in this contract: 1) evaluating tissues and vaginal cytology slides sent from other toxicology labs (spermatid count and vaginal cytology evaluation, SCVCE), 2) performing in vivo toxicity studies in-house. 3. The Contractor purchase healthy animals from a source approved by the Project Officer, and maintain them in environmentally-controlled facilities with a controlled light cycle and controlled temperature and humidity. 4. The Contractor shall be required to prepare protocols and standard operating procedures (SOPs) for studies as they are needed. 5. There are two parts of the SCVCE work: (1) tissue/slide evaluation and reporting, and (2) technical assistance to other NTP laboratories.
| Chan, Sherine S L; Santos, Janine H; Meyer, Joel N et al. (2007) Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Environ Mol Mutagen 48:190-200 |
| Bishop, Jack B; Witt, Kristine L; Tice, Raymond R et al. (2004) Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage. Environ Mol Mutagen 43:3-9 |
| Witt, Kristine L; Tice, Raymond R; Wolfe, Gary W et al. (2004) Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen 44:321-8 |
