The objective of this contract is to determine the potential toxicity/carcinogenicity of three chemicals via the inhalation route of exposure to F344 rats and B6C3F1 mice. The project involves prechronic and chronic studies of divinylbenzene, stoddard solvent (type II-C) and optionally, stoddard solvent (type I-A). The 14-day studies involve the treatment of 5 animals per sex/species at 5 exposure concentrations plus controls. The 90-day studies involve the treatment of 10 animals per sex/species at 5 exposure concentrations plus controls. Special studies in the subchronic study include hematology, clinical chemistries, SMVCE and micronuclei (mice). The 2-year studies involve the treatment of 50 animals per sex/species at 3 exposure concentrations plus controls.

Project Start
1997-07-31
Project End
Budget Start
1998-04-14
Budget End
1999-02-01
Support Year
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Battelle Memorial Institute
Department
Type
DUNS #
City
Columbus
State
OH
Country
United States
Zip Code
43201