Abstract

The objective of this contract is to obtain information on the ability of chemicals under study by the National Toxicology Program to induce chromosomal damage in the bone marrow cells of treated laboratory mice. Specifically, the contract laboratory will conduct mouse bone marrow micronucleus tests on chemicals supplied by the NTP chemical repository using a protocol prescribed by the Program. Results of these tests will be considered along with results from other genetic toxicity tests to help reach conclusions on the possible carcinogenic and germ cell mutagenic activity of the test chemicals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research and Development Contracts (N01)
Project #
N01ES085208-002
Application #
2310938
Study Section
Project Start
1988-03-31
Project End
Budget Start
1989-05-02
Budget End
1990-03-30
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Environmental Health Research & Testing
Department
Type
DUNS #
City
Lexington
State
KY
Country
United States
Zip Code
40503

  Publications

Shelby, M D; Erexson, G L; Hook, G J et al. (1993) Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen 21:160-79
Tice, R R; Erexson, G L; Shelby, M D (1990) The induction of micronucleated polychromatic erythrocytes in mice using single and multiple treatments. Mutat Res 234:187-93