The objective of this project is to characterize:dose-response relationships and toxicity of oxazepam administered in dosed feed to rats and mice in 90-day subchronic and 2-year chronic studies. Animals will be administered dosed feed 7 days per week for 90 days or 2 years. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations, Sperm morphology/vaginal cytology, neurobehavioral evaluations, and blood oxazepam concentrations will be evaluated in the 90-day study. A 65-week interim sacrifice including histopathology and blood oxazepam concentrations will be evaluated in the chronic study. In addition, special neurobehavior indices will be evaluated prior to the start of the chronic study and at 6, 12, 18, and 24 months of the chronic study. The results of the 90-day study will be used by NTP to establish doses to be used in the chronic study. The results of the chronic study will be utilized in evaluation of the toxicologic and carcinogenic potential of oxazepam.

Project Start
1987-12-18
Project End
1992-03-17
Budget Start
1989-09-27
Budget End
1990-12-17
Support Year
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Battelle Memorial Institute
Department
Type
DUNS #
City
Columbus
State
OH
Country
United States
Zip Code
43201