The objective of this contract is to test approximately 100 chemicals for their ability to induce chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells. All test chemicals will be provided to the contractor as coded samples. The contractor will use a standardized protocol developed by previous NTP contractors (Galloway et. al., 1985), which includes testing the chemicals both with and without exogenous metabolic activation. Some chemicals may be selected for in-depth analysis to determine mechanisms of action or possible protocol modifications.

Project Start
1988-06-30
Project End
1992-06-29
Budget Start
1990-03-15
Budget End
1991-06-29
Support Year
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Sitek Research Laboratories
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20850
Zeiger, E; Erexson, G; Mortelmans, K et al. (1997) Genetic toxicity studies of 1,2,3,4-tetrahydro-9-acridinamine (tacrine). Mutat Res 393:189-97