Studies of Chemical Disposition in Mammals

Sipes, I G.

Abstract

The purpose of this contract is to obtain detailed chemical disposition data from approximately 5 studies of selected environment contaminants or model compounds per year. A study consists of the determination of absorption, distribution, metabolism and excretion of a selected compound in a given species. Most studies will be conducted in Fischer 344 rats; however, some studies may be required in other species.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Research and Development Contracts (N01)
• Project #: N01ES085230-005
• Application #: 2311162
• Project Start: 1988-09-30
• Project End: 1993-09-14
• Budget Start: 1992-06-01
• Budget End: 1993-09-14
• Fiscal Year: 1992

Institution

• Name: University of Arizona
• Department: Pharmacology
• Type: Schools of Pharmacy
• City: Tucson
• State: AZ
• Country: United States
• Zip Code: 85721

Publications

Doerr, J K; Sipes, I G (1996) Ovarian toxicity and metabolism of 4-vinylcyclohexene and analogues in B6C3F1 mice: structure-activity study of 4-vinylcyclohexene and analogues. Adv Exp Med Biol 387:377-84

Doerr, J K; Hooser, S B; Smith, B J et al. (1995) Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F1 mice: role of diepoxides. Chem Res Toxicol 8:963-9

Salyers, K L; Barr, J; Sipes, I G (1994) In vitro metabolism of theophylline by rat and human liver tissue. Xenobiotica 24:389-99

Zheng, W; Winter, S M; Kattnig, M J et al. (1994) Tissue distribution and elimination of indium in male Fischer 344 rats following oral and intratracheal administration of indium phosphide. J Toxicol Environ Health 43:483-94

Zheng, W; Sipes, I G; Carter, D E (1993) Determination of parts-per-billion concentrations of indium in biological materials by electrothermal atomic absorption spectrometry following ion pair extraction. Anal Chem 65:2174-6

Zheng, W; Winter, S M; Mayersohn, M et al. (1993) Toxicokinetics of sulfasalazine (salicylazosulfapyridine) and its metabolites in B6C3F1 mice. Drug Metab Dispos 21:1091-7

Stine, E R; Gunawardhana, L; Sipes, I G (1991) The acute hepatotoxicity of the isomers of dichlorobenzene in Fischer-344 and Sprague-Dawley rats: isomer-specific and strain-specific differential toxicity. Toxicol Appl Pharmacol 109:472-81