The objectives of this project are two-fold. One is to develop, evaluate, and report the methodology and result for generation and monitoring techniques necessary for conducting chronic inhalation studies with ozone and NNK. The second is to characterize dose-response relationships, toxicity, and carcinogenic potential of ozone administered by inhalation to rats and mice in 2-year chronic studies while being given injections of NNK three times a week for 20 weeks. Animals will be exposed for 6 hours per day, 5 days per week for 2 years. At the end of two years, all animals will be given gross and microscopic histopathologic evaluations.

Project Start
1989-06-30
Project End
1993-03-02
Budget Start
1991-08-30
Budget End
1992-03-31
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Battelle Pacific Northwest Laboratories
Department
Type
DUNS #
032987476
City
Richland
State
WA
Country
United States
Zip Code
99352