Abstract

The offeror shall serve as a statistical coordinating center for the pediatric cohort of the Cooperative Study of Sickle Cell Disease (CSSCD). The Statistical Coordinating Center has as its major responsibility participation in the statistical design of the study and the development of operational and analytical methodology. The Center is responsible for data management and analysis, generation and distribution of reports, development of forms design and Manual of Operations, and.assistance with meetings. Under the direction of the Program Office, the statistical coordinating center has the overall responsibility of ensuring that the provisions of the Manual of Operations are carried-out by all investigating groups. Total study enrollment is estimated at 440 children. Contract performance is divided into three stages: I- Protocol/Manual of Operations Development; II. Patient Entry and follow-Up; and III. Data Analysis, Documentation, and Manuscript Preparation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB047110-002
Application #
2312719
Study Section
Project Start
1994-04-01
Project End
2000-03-31
Budget Start
1995-02-10
Budget End
1997-03-31
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
02472

  Publications

Galarneau, Geneviève; Coady, Sean; Garrett, Melanie E et al. (2013) Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients. Blood 122:434-42
Boyd, Jessica H; DeBaun, Michael R; Morgan, Wayne J et al. (2009) Lower airway obstruction is associated with increased morbidity in children with sickle cell disease. Pediatr Pulmonol 44:290-6
Phillips, Keydra L; An, Ping; Boyd, Jessica H et al. (2008) Major gene effect and additive familial pattern of inheritance of asthma exist among families of probands with sickle cell anemia and asthma. Am J Hum Biol 20:149-53
Boyd, Jessica H; Macklin, Eric A; Strunk, Robert C et al. (2007) Asthma is associated with increased mortality in individuals with sickle cell anemia. Haematologica 92:1115-8
Boyd, Jessica H; Macklin, Eric A; Strunk, Robert C et al. (2006) Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia. Blood 108:2923-7
Glassberg, Jeffrey; Spivey, John F; Strunk, Robert et al. (2006) Painful episodes in children with sickle cell disease and asthma are temporally associated with respiratory symptoms. J Pediatr Hematol Oncol 28:481-5
Uong, Elizabeth C; Boyd, Jessica Henderson; DeBaun, Michael R (2006) Daytime pulse oximeter measurements do not predict incidence of pain and acute chest syndrome episodes in sickle cell anemia. J Pediatr 149:707-9
Hsu, Lewis L; Miller, Scott T; Wright, Elizabeth et al. (2003) Alpha Thalassemia is associated with decreased risk of abnormal transcranial Doppler ultrasonography in children with sickle cell anemia. J Pediatr Hematol Oncol 25:622-8
Pegelow, Charles H; Macklin, Eric A; Moser, Franklin G et al. (2002) Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. Blood 99:3014-8
Miller, S T; Macklin, E A; Pegelow, C H et al. (2001) Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease. J Pediatr 139:385-90

Showing the most recent 10 out of 12 publications