Abstract

This study's objective is to determine if transfusion is followed by the activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affecting prognosis. It also will evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion. The study consists of 11 clinical sites, a central laboratory, and a medical coordinating center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB057117-007
Application #
6199759
Study Section
Project Start
1994-12-01
Project End
2000-06-30
Budget Start
1999-11-30
Budget End
2000-06-30
Support Year
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Miriam Hospital
Department
Type
DUNS #
039318308
City
Providence
State
RI
Country
United States
Zip Code
02906

  Publications

Asmuth, David M; Busch, Michael P; Laycock, Megan E et al. (2004) Hepatitis B and C viral load changes following initiation of highly active antiretroviral therapy (HAART) in patients with advanced HIV infection. Antiviral Res 63:123-31
Ariga, Hiromichi; Lee, Tzong-Hae; Laycock, Megan E et al. (2003) Residual WBC subsets in filtered prestorage RBCs. Transfusion 43:98-106
Asmuth, David M; Kalish, Leslie A; Laycock, Megan E et al. (2003) Absence of HBV and HCV, HTLV-I and -II, and human herpes virus-8 activation after allogeneic RBC transfusion in patients with advanced HIV-1 infection. Transfusion 43:451-8
Murphy, Edward L; Grant, Robert M; Kropp, Jerry et al. (2003) Increased human T-lymphotropic virus type II proviral load following highly active retroviral therapy in HIV-coinfected patients. J Acquir Immune Defic Syndr 33:655-6
Yomtovian, R; Gernsheimer, T; Assmann, S F et al. (2001) WBC reduction in RBC concentrates by prestorage filtration: multicenter experience. Transfusion 41:1030-6
Collier, A C; Kalish, L A; Busch, M P et al. (2001) Leukocyte-reduced red blood cell transfusions in patients with anemia and human immunodeficiency virus infection: the Viral Activation Transfusion Study: a randomized controlled trial. JAMA 285:1592-601
Para, M F; Kalish, L A; Collier, A C et al. (2001) Qualitative and quantitative PCR measures of cytomegalovirus in patients with advanced HIV infection who require transfusions. J Acquir Immune Defic Syndr 26:320-5
Eisenbud, R; Assmann, S F; Kalish, L A et al. (2001) Differences in difficulty adjudicating clinical events in patients with advanced HIV disease. J Acquir Immune Defic Syndr 28:43-6
Lederman, M M; Kalish, L A; Asmuth, D et al. (2000) 'Modeling' relationships among HIV-1 replication, immune activation and CD4+ T-cell losses using adjusted correlative analyses. AIDS 14:951-8