This study's objective is to determine if transfusion is followed by the activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affecting prognosis. It also will evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion. The study consists of 11 clinical sites, a central laboratory, and a medical coordinating center.

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB057119-003
Application #
2593186
Study Section
Project Start
1994-12-01
Project End
1998-11-30
Budget Start
1997-06-17
Budget End
1998-11-30
Support Year
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
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