Abstract

The contractor shall serve as the Medical Coordinating Center for the Viral Activation Transfusion Study. This study is designed to determine if transfusion is followed by activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affects prognosis. It will also evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB057127-001
Application #
2312791
Study Section
Project Start
1994-12-01
Project End
1997-11-30
Budget Start
1995-06-15
Budget End
1996-05-31
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
02472

  Publications

Asmuth, David M; Busch, Michael P; Laycock, Megan E et al. (2004) Hepatitis B and C viral load changes following initiation of highly active antiretroviral therapy (HAART) in patients with advanced HIV infection. Antiviral Res 63:123-31
Asmuth, David M; Kalish, Leslie A; Laycock, Megan E et al. (2003) Absence of HBV and HCV, HTLV-I and -II, and human herpes virus-8 activation after allogeneic RBC transfusion in patients with advanced HIV-1 infection. Transfusion 43:451-8
Murphy, Edward L; Grant, Robert M; Kropp, Jerry et al. (2003) Increased human T-lymphotropic virus type II proviral load following highly active retroviral therapy in HIV-coinfected patients. J Acquir Immune Defic Syndr 33:655-6
Drew, W Lawrence; Chou, Sunwen; Miner, Richard C et al. (2002) Cytomegalovirus glycoprotein B groups in human immunodeficiency virus-infected patients with incident retinitis. J Infect Dis 186:114-7
Kennedy, Melanie S; Kalish, Leslie A; Mohandas, Kala et al. (2002) The transfusion trigger and number of units transfused in patients with HIV: associations with disease stage and functional status. Transfusion 42:456-61
Yomtovian, R; Gernsheimer, T; Assmann, S F et al. (2001) WBC reduction in RBC concentrates by prestorage filtration: multicenter experience. Transfusion 41:1030-6
Collier, A C; Kalish, L A; Busch, M P et al. (2001) Leukocyte-reduced red blood cell transfusions in patients with anemia and human immunodeficiency virus infection: the Viral Activation Transfusion Study: a randomized controlled trial. JAMA 285:1592-601
Para, M F; Kalish, L A; Collier, A C et al. (2001) Qualitative and quantitative PCR measures of cytomegalovirus in patients with advanced HIV infection who require transfusions. J Acquir Immune Defic Syndr 26:320-5
Eisenbud, R; Assmann, S F; Kalish, L A et al. (2001) Differences in difficulty adjudicating clinical events in patients with advanced HIV disease. J Acquir Immune Defic Syndr 28:43-6
Kruskall, M S; Lee, T H; Assmann, S F et al. (2001) Survival of transfused donor white blood cells in HIV-infected recipients. Blood 98:272-9