Abstract

The Contractor shall maintain a colony of forty-nine (49) NHLBI-owned chimpanzees that are available for research on posttransfusion viral hepatitis or AIDS. Proposals to utilize these animals are initiated by the scientific community and reviewed for scientific merit and program relevance by NHLBI Staff and a PHS AIDS Animal Model Committee. Chimpanzees are made available for approved research under a separate contract between the user and the contractor. Laboratory and technical support will also be provided under this separate contract.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB077029-007
Application #
3646085
Study Section
Project Start
1987-06-18
Project End
1992-06-17
Budget Start
1991-04-25
Budget End
1992-06-17
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245

  Publications

Williams-Blangero, S; Butler, T; Brasky, K et al. (1994) Heritabilities of clinical chemical traits in chimpanzees. Lab Anim Sci 44:141-3
Williams-Blangero, S; Brasky, K; Butler, T et al. (1993) Genetic analysis of hematological traits in chimpanzees (Pan troglodytes). Hum Biol 65:1013-24
Castro, B A; Homsy, J; Lennette, E et al. (1992) HIV-1 expression in chimpanzees can be activated by CD8+ cell depletion or CMV infection. Clin Immunol Immunopathol 65:227-33
Lanford, R E; Notvall, L; Barbosa, L H et al. (1991) Evaluation of a chimpanzee colony for antibodies to hepatitis C virus. J Med Virol 34:148-53
Prince, A M; Reesink, H; Pascual, D et al. (1991) Prevention of HIV infection by passive immunization with HIV immunoglobulin. AIDS Res Hum Retroviruses 7:971-3
Warren, R Q; Wolf, H; Shuler, K R et al. (1990) Synthetic peptides define the fine specificity of the human immunodeficiency virus (HIV) gp160 humoral immune response in HIV type 1-infected chimpanzees. J Virol 64:486-92
Castro, B A; Walker, C M; Tateno, M et al. (1989) Human immunodeficiency virus (HIV) from experimentally infected chimpanzees: isolation and characterization. J Med Primatol 18:337-42
Taylor, A F; Smith, M; Eichberg, J W (1989) Inguinal hernial surgery in an infant chimpanzee. J Med Primatol 18:415-7
Robinson Jr, W E; Montefiori, D C; Mitchell, W M et al. (1989) Antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1-infected and passively immunized chimpanzees. Proc Natl Acad Sci U S A 86:4710-4
Prince, A M; Horowitz, B; Baker, L et al. (1988) Failure of a human immunodeficiency virus (HIV) immune globulin to protect chimpanzees against experimental challenge with HIV. Proc Natl Acad Sci U S A 85:6944-8