The objectives of this contract are to 1) identify interference by penicillin prophylaxis on the acquisition of antibodies to S. pneumoniae; 2) assess the emergence of penicillin resistant S. pneumoniae; 3) upon cessation of penicillin prophylaxis, compare the incidence of documented bacterial infection in that patient population with children receiving penicillin; 4) to determine if continued penicillin prophylaxis beyond 5 years of age interferes with the serum antibody response to booster immunization with the pneumococcal vaccine or subsequent development of natural serum antibodies to S. pneumoniae; 5) to determine, in children with S. pneumoniae infection, if they had detectable serum antibody to the infecting serotype; and 6) to determine if patients who develop severe pneumococcal infection have lower serum antibody titers to S. pneumoniae before infection or respond suboptimally to the pneumococcal vaccine as compared to patients without infection.

Agency
National Institute of Health (NIH)
Institute
Division of Blood Diseases And Resources (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HB087050-006
Application #
2313219
Study Section
Project Start
1988-07-15
Project End
1995-07-14
Budget Start
1991-04-25
Budget End
1992-07-14
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
James N. Gamble Institute of Medical Research
Department
Type
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45219