The Iron Overload and Hereditary Hemochromatosis Study is an epidemiologic study of the prevalence, genetic and environmental determinants, and potential clinical, personal, and societal impact of iron overload and hereditary hemochromatosis in a multi-center, multi-ethnic, primary care-based sample of 100,000 adults. The information will be used to determine the feasibility and potential individual and public health benefits and risks of primary care-based screening and intervention for iron overload and hereditary hemochromatosis. The 100,000 participants will be recruited from five field centers for screening. Following the screening, a clinical examination will be conducted in selected individuals. The final component of the study is a family study which will use genome scanning and assessment of linkage to identify genetic variants related to the expression of iron overload and hereditary hemochromatosis disorders.

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Kaiser Foundation Research Institute
United States
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Murray, Joseph A; McLachlan, Stela; Adams, Paul C et al. (2013) Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. Clin Gastroenterol Hepatol 11:808-14
McLaren, Christine E; McLachlan, Stela; Garner, Chad P et al. (2012) Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations. PLoS One 7:e38339
Adams, Paul C; Speechley, Mark; Barton, James C et al. (2012) Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening study. Hepatology 55:1722-6
McLaren, Christine E; Garner, Chad P; Constantine, Clare C et al. (2011) Genome-wide association study identifies genetic loci associated with iron deficiency. PLoS One 6:e17390
McLaren, Christine E; Barton, James C; Eckfeldt, John H et al. (2010) Heritability of serum iron measures in the hemochromatosis and iron overload screening (HEIRS) family study. Am J Hematol 85:101-5
Speechley, Mark; Barton, James C; Passmore, Leah et al. (2009) Potential nonresponse bias in a clinical examination after initial screening using iron phenotyping and HFE genotyping in the hemochromatosis and iron overload screening study. Genet Test Mol Biomarkers 13:721-8
McLaren, Gordon D; Gordeuk, Victor R (2009) Hereditary hemochromatosis: insights from the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Hematology Am Soc Hematol Educ Program :195-206
Gordeuk, Victor R; Reboussin, David M; McLaren, Christine E et al. (2008) Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population. Am J Hematol 83:618-26
McLaren, Christine E; Gordeuk, Victor R; Chen, Wen-Pin et al. (2008) Bivariate mixture modeling of transferrin saturation and serum ferritin concentration in Asians, African Americans, Hispanics, and whites in the Hemochromatosis and Iron Overload Screening (HEIRS) Study. Transl Res 151:97-109
Barton, James C; Leiendecker-Foster, Catherine; Reboussin, David M et al. (2008) Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS study. Thyroid 18:831-8

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