The University of California, Irvine will serve as the echocardiography reading center for the Coronary Artery Risk Development in Young Adults (CARDIA) Study which is a study of the distribution and change in risk factors during young adulthood in black and white men and women. The baseline CARDIA examination began in June 1985 with the goal of recruiting and examining 5,000 men and women aged 18-30 years in four communities. Participants were selected from the total population, selected census tracts or, in the case of one Center, the membership of a large health plan. Participants were successfully selected to obtain a cohort with approximately equal representation by blacks and whites, men and women, those aged 18-24 and 25-30, and those with no more than a high school education and more than a high school education. The study involves a Coordinating Center (which subcontracts for the Pulmonary Function Reading Center and the Central Lipid Laboratory), four field Centers and the Echocardiography Reading Center. A baseline echocardiography was performed during the Year 5 examination and this performance period will allow for an additional examination and further longitudinal analysis of the cohort during the Year 10 examination on cohort participants at two of the four field centers. The main objective of the echocardiography compent is to describe and identify determinants of change in left ventricular mass.

Project Start
1994-02-01
Project End
1998-11-30
Budget Start
1995-06-27
Budget End
1997-05-31
Support Year
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Other Domestic Higher Education
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Gong, J; Nishimura, K K; Fernandez-Rhodes, L et al. (2018) Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. Int J Obes (Lond) 42:384-390
Fernández-Rhodes, Lindsay; Gong, Jian; Haessler, Jeffrey et al. (2017) Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Hum Genet 136:771-800
Wang, Heming; Choi, Yoonha; Tayo, Bamidele et al. (2017) Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome. Genet Epidemiol 41:122-135
Manichaikul, Ani; Wang, Xin-Qun; Zhao, Wei et al. (2016) Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis. J Lipid Res 57:433-42
Ehret, Georg B (see original citation for additional authors) (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet 48:1171-1184
Fuller-Rowell, Thomas E; Curtis, David S; Doan, Stacey N et al. (2015) Racial disparities in the health benefits of educational attainment: a study of inflammatory trajectories among African American and white adults. Psychosom Med 77:33-40
Cho, Hyong Jin; Seeman, Teresa E; Kiefe, Catarina I et al. (2015) Sleep disturbance and longitudinal risk of inflammation: Moderating influences of social integration and social isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Brain Behav Immun 46:319-26
Shetty, Priya B; Tang, Hua; Feng, Tao et al. (2015) Variants for HDL-C, LDL-C, and triglycerides identified from admixture mapping and fine-mapping analysis in African American families. Circ Cardiovasc Genet 8:106-13
Hansen, J G; Gao, W; Dupuis, J et al. (2015) Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study. Respir Res 16:81
Guan, Weihua; Steffen, Brian T; Lemaitre, Rozenn N et al. (2014) Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. Circ Cardiovasc Genet 7:321-331

Showing the most recent 10 out of 116 publications