Abstract

This contract is for a clinical center which is one of an estimated twenty-five centers that will conduct a large scale clinical trial on left ventricular dysfunction. The primary objective of the trial is to answer two questions: (1) In patients with moderate left ventricular dysfunction and little or no overt heart failure, can death be prevented? (2) Is mortality reduced by treatment in those with manifest heart failure? Two concurrent but distinct randomized double blind controlled trials will be conducted. The first will be the Prevention Trial and will be placebo controlled. The second will be the Treatment Trial and patients will be randomized to """"""""standard"""""""" treatment + placebo or """"""""standard"""""""" treatment + active agent. The Prevention Trial has an anticipated enrollment of at least 4,000 patients and the Treatment Trial of at least 2,000 patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Epidemiology And Clinical Applications (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HC055010-005
Application #
3647165
Study Section
Project Start
1985-07-15
Project End
1991-10-14
Budget Start
1988-06-28
Budget End
1989-04-14
Support Year
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Kronenberg, M W; Konstam, M A; Edens, T R et al. (1998) Factors influencing exercise performance in patients with left ventricular dysfunction. SOLVD Investigators. Studies of Left Ventricular Dysfunction. J Card Fail 4:159-67
Patten, R D; Kronenberg, M W; Benedict, C R et al. (1997) Acute and long-term effects of the angiotensin-converting enzyme inhibitor, enalapril, on adrenergic activity and sensitivity during exercise in patients with left ventricular systolic dysfunction. Am Heart J 134:37-43
Mirsky, I; Aoyagi, T; Ihara, T et al. (1995) Contractile state is the major determinant of functional outcome in patients with left ventricular dysfunction treated with enalapril. Eur Heart J 16:808-17
Konstam, M A; Kronenberg, M W; Rousseau, M F et al. (1993) Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD (Studies of Left Ventricular Dysfunction) Investigators. Circulation 88:2277-83
Konstam, M A; Kronenberg, M W; Udelson, J E et al. (1992) Effectiveness of preload reserve as a determinant of clinical status in patients with left ventricular systolic dysfunction. The SOLVD Investigators. Am J Cardiol 69:1591-5
Konstam, M A; Rousseau, M F; Kronenberg, M W et al. (1992) Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. SOLVD Investigators. Circulation 86:431-8
Desnoyers, M R; Isner, J M; Pandian, N G et al. (1988) Clinical and noninvasive hemodynamic results after aortic balloon valvuloplasty for aortic stenosis. Am J Cardiol 62:1078-84
Isner, J M; Samuels, D A; Slovenkai, G A et al. (1988) Mechanism of aortic balloon valvuloplasty: fracture of valvular calcific deposits. Ann Intern Med 108:377-80
Isner, J M; Salem, D N; Desnoyers, M R et al. (1988) Dual balloon technique for valvuloplasty of aortic stenosis in adults. Am J Cardiol 61:583-9
Salem, D N; Isner, J M (1987) Percutaneous aortic valvuloplasty. Chest 92:326-9