Abstract

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Epidemiology And Clinical Applications (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HC095167-003
Application #
6370258
Study Section
Project Start
1999-01-15
Project End
2009-01-14
Budget Start
2000-10-01
Budget End
2001-04-30
Support Year
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Steffen, Brian T; Duprez, Daniel; Bertoni, Alain G et al. (2018) Lp(a) [Lipoprotein(a)]-Related Risk of Heart Failure Is Evident in Whites but Not in Other Racial/Ethnic Groups. Arterioscler Thromb Vasc Biol 38:2498-2504
Bhambhani, Vijeta; Kizer, Jorge R; Lima, Joao A C et al. (2018) Predictors and outcomes of heart failure with mid-range ejection fraction. Eur J Heart Fail 20:651-659
Mortensen, Martin Bødtker; Falk, Erling; Li, Dong et al. (2018) Statin Trials, Cardiovascular Events, and Coronary Artery Calcification: Implications for a Trial-Based Approach to Statin Therapy in MESA. JACC Cardiovasc Imaging 11:221-230
Steffen, Brian T; Duprez, Daniel; Szklo, Moyses et al. (2018) Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol 12:1404-1412
Austin, Thomas R; Wiggins, Kerri L; Blackshear, Chad et al. (2018) Atrial fibrillation in an African-American cohort: The Jackson Heart Study. Clin Cardiol 41:1049-1054
Ostovaneh, Mohammad R; Ambale-Venkatesh, Bharath; Fuji, Tomoki et al. (2018) Association of Liver Fibrosis With Cardiovascular Diseases in the General Population: The Multi-Ethnic Study of Atherosclerosis (MESA). Circ Cardiovasc Imaging 11:e007241
Hui, Tsz Him; McClelland, Robyn L; Allison, Matthew A et al. (2018) The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 269:86-91
Vella, Chantal A; Cushman, Mary; Van Hollebeke, Rachel B et al. (2018) Associations of Abdominal Muscle Area and Radiodensity with Adiponectin and Leptin: The Multiethnic Study of Atherosclerosis. Obesity (Silver Spring) 26:1234-1241
Longstreth Jr, W T; Gasca, Natalie C; Gottesman, Rebecca F et al. (2018) Adjudication of Transient Ischemic Attack and Stroke in the Multi-Ethnic Study of Atherosclerosis. Neuroepidemiology 50:23-28
Savji, Nazir; Meijers, Wouter C; Bartz, Traci M et al. (2018) The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF. JACC Heart Fail 6:701-709

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