Abstract

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Epidemiology And Clinical Applications (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HC095169-000
Application #
6018088
Study Section
Project Start
1999-01-15
Project End
2009-01-14
Budget Start
1999-01-15
Budget End
2000-01-14
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
La Biomed Research Institute/ Harbor UCLA Medical Center
Department
Type
DUNS #
City
Torrance
State
CA
Country
United States
Zip Code
90502

  Publications

Bell, Elizabeth J; Decker, Paul A; Tsai, Michael Y et al. (2018) Hepatocyte growth factor is associated with progression of atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 272:162-167
Haljas, Kadri; Amare, Azmeraw T; Alizadeh, Behrooz Z et al. (2018) Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits. Psychosom Med 80:242-251
Besser, Lilah M; Rodriguez, Daniel A; McDonald, Noreen et al. (2018) Neighborhood built environment and cognition in non-demented older adults: The Multi-Ethnic Study of Atherosclerosis. Soc Sci Med 200:27-35
Gao, Chuan; Langefeld, Carl D; Ziegler, Julie T et al. (2018) Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans. Obesity (Silver Spring) 26:202-212
Steffen, Brian T; Duprez, Daniel; Bertoni, Alain G et al. (2018) Lp(a) [Lipoprotein(a)]-Related Risk of Heart Failure Is Evident in Whites but Not in Other Racial/Ethnic Groups. Arterioscler Thromb Vasc Biol 38:2498-2504
Vella, Chantal A; Allison, Matthew A (2018) Associations of abdominal intermuscular adipose tissue and inflammation: The Multi-Ethnic Study of Atherosclerosis. Obes Res Clin Pract 12:534-540
Bhambhani, Vijeta; Kizer, Jorge R; Lima, Joao A C et al. (2018) Predictors and outcomes of heart failure with mid-range ejection fraction. Eur J Heart Fail 20:651-659
Hastert, T A; de Oliveira Otto, M C; Lê-Scherban, F et al. (2018) Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: results from the Multi-Ethnic Study of Atherosclerosis. Int J Obes (Lond) 42:433-440
Mortensen, Martin Bødtker; Falk, Erling; Li, Dong et al. (2018) Statin Trials, Cardiovascular Events, and Coronary Artery Calcification: Implications for a Trial-Based Approach to Statin Therapy in MESA. JACC Cardiovasc Imaging 11:221-230
Heckbert, Susan R; Austin, Thomas R; Jensen, Paul N et al. (2018) Yield and consistency of arrhythmia detection with patch electrocardiographic monitoring: The Multi-Ethnic Study of Atherosclerosis. J Electrocardiol 51:997-1002

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