Abstract

The objective of this contract is to maintain and operate a Synthetic Peptide Facility capable of synthesizing gram-scale quantities (1-50 grams via single-batch or multiple small-batch preparation) of previously prepared peptides for toxicology studies, primates testing and clinical investigation as well as smaller quantities (5-100 milligrams) of new peptides for initial biological testing in small animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD002906-016
Application #
2314419
Study Section
Project Start
1989-11-30
Project End
1994-11-29
Budget Start
1991-11-30
Budget End
1992-11-29
Support Year
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Kawate, Noritoshi; Tsuji, Makoto; Tamada, Hiromichi et al. (2003) Changes of messenger RNAs encoding vascular endothelial growth factor and its receptors during the development and maintenance of caprine corpora lutea. Mol Reprod Dev 64:166-71
Ohta, Hiroshi; Tohda, Akira; Nishimune, Yoshitake (2003) Proliferation and differentiation of spermatogonial stem cells in the w/wv mutant mouse testis. Biol Reprod 69:1815-21
Kawate, Noritoshi; Tsuji, Makoto; Tamada, Hiromichi et al. (2002) Inhibition of luteinizing hormone receptor expression during the development of caprine corpora lutea by administration of gonadotropin-releasing hormone antagonist. Mol Reprod Dev 63:444-50
Mann, D R; Akinbami, M A; Gould, K G et al. (2002) Leptin and thyroxine during sexual development in male monkeys: effect of neonatal gonadotropin-releasing hormone antagonist treatment and delayed puberty on the developmental pattern of leptin and thyroxine secretion. Eur J Endocrinol 146:891-8
Agersborg, S S; Garza, K M; Tung, K S (2001) Intestinal parasitism terminates self tolerance and enhances neonatal induction of autoimmune disease and memory. Eur J Immunol 31:851-9
Babu, P S; Danilovich, N; Sairam, M R (2001) Hormone-induced receptor gene splicing: enhanced expression of the growth factor type I follicle-stimulating hormone receptor motif in the developing mouse ovary as a new paradigm in growth regulation. Endocrinology 142:381-9
Tohda, A; Matsumiya, K; Tadokoro, Y et al. (2001) Testosterone suppresses spermatogenesis in juvenile spermatogonial depletion (jsd ) mice. Biol Reprod 65:532-7
Mann, D R; Akinbami, M A; Lunn, S F et al. (2000) Endocrine-immune interaction: alteractions in immune function resulting from neonatal treatment with a GnRH antagonist and seasonality in male primates. Am J Reprod Immunol 44:30-40
Sharpe, R M; Walker, M; Millar, M R et al. (2000) Effect of neonatal gonadotropin-releasing hormone antagonist administration on sertoli cell number and testicular development in the marmoset: comparison with the rat. Biol Reprod 62:1685-93
Lou, Y H; Park, K K; Agersborg, S et al. (2000) Retargeting T cell-mediated inflammation: a new perspective on autoantibody action. J Immunol 164:5251-7

Showing the most recent 10 out of 36 publications