The objectives of this contract are to design, synthesize and test peptide antagonists which have very low histamine releasing properties (equivalent to LHRH, or less) and which completely inhibit ovulation in rats, s.c., at one-tenth the dose of the most potent antagonists currently available, such as Nal-Glu or Antide. Such antagonists should, desirably, also be devoid of (or have minimal) ancillary endocrine, central nervous system, cardiovascular and other side effects.

Project Start
1990-11-01
Project End
1992-10-31
Budget Start
1991-09-26
Budget End
1992-10-31
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Salk Institute for Biological Studies
Department
Type
DUNS #
005436803
City
La Jolla
State
CA
Country
United States
Zip Code
92037