Abstract

Perform a prospective study to evaluate the relationship between contraceptive steroid plasma levels during oral contraceptive (OC) use and the extent of OC-induced alterations in antithrombin III activity, high density lipoprotein cholesterol concentration, blood pressure, and other physiological factors that appear to be involved in the pathogenesis of cardiovascular disease that is attributable to oral contraceptives.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD032816-002
Application #
3650571
Study Section
Project Start
1983-09-15
Project End
1987-03-14
Budget Start
1985-06-28
Budget End
1986-09-14
Support Year
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Saleh, W A; Burkman, R T; Zacur, H A et al. (1993) A randomized trial of three oral contraceptives: comparison of bleeding patterns by contraceptive types and steroid levels. Am J Obstet Gynecol 168:1740-5;discussion 1745-7
Zacur, H A; Burkman, R T; Kimball, A W et al. (1992) Existence of multiple peaks in plasma ethinyl estradiol and norethindrone after oral administration of a contraceptive pill. J Clin Endocrinol Metab 75:1268-72
Zacur, H A; Linkins, S; Chang, V et al. (1991) Ethinyl estradiol and norethindrone radioimmunoassay following Sephadex LH-20 column chromatography. Clin Chim Acta 204:209-15
Murphy, A A; Zacur, H A; Charache, P et al. (1991) The effect of tetracycline on levels of oral contraceptives. Am J Obstet Gynecol 164:28-33
Xu, L; Chang, V; Murphy, A et al. (1990) Antinuclear antibodies in sera of patients with recurrent pregnancy wastage. Am J Obstet Gynecol 163:1493-7
Murphy, A; Cropp, C S; Smith, B S et al. (1990) Effect of low-dose oral contraceptive on gonadotropins, androgens, and sex hormone binding globulin in nonhirsute women. Fertil Steril 53:35-9
Sullivan-Nelson, M; Kuller, J A; Zacur, H A (1989) Clinical use of oral contraceptives administered vaginally: a case report. Fertil Steril 52:864-6