The goal of the proposed studies is to provide a formulation of known agents into a vaginal contraceptive of high effectiveness together with ability to: 1) provide rapid spermicide delivery and long-acting spermicidal activity after a single application, 2) protect the user against AIDS (HIV) and other STDs, 3) protect vaginal and cervical epithelia from irritation, 4) enhance penetration of spermicide into cervical mucus, 5) demonstrate low systemic bioavailability and, finally 6) be pharmaceutically and cosmetically acceptable.
| Zavos, P M; Correa, J R; Zarmakoupis-Zavos, P N (1998) Assessment of a tablet drug delivery system incorporating nonoxynol-9 coprecipitated with polyvinylpyrrolidone in preventing the onset of pregnancy in rabbits. Fertil Steril 69:768-73 |
| Zavos, P M; Correa, J R (1997) Vaginal delivery of new formulations of nonoxynol-9 coprecipitated with polyvinylpyrrolidone in rabbits. Comparisons between two formulation delivery systems. Contraception 56:123-7 |
| Zavos, P M; Correa, J R; Nosek, D et al. (1996) Assessment of new formulations of nonoxynol-9 coprecipitated with polyvinylpyrrolidone and iodine as possible vaginal contraceptives. Fertil Steril 66:729-33 |
| Zavos, P M; Correa, J R; Nosek, D et al. (1996) Comparative spermicidal performance of iodinated and non-iodinated contraceptive formulations of nonoxynol-9 co-precipitated with polyvinylpyrrolidone. Contraception 54:39-41 |
