Peptide Antagonists of Lhrh as Gonadotropin Inhibitors

Coy, David H.

Abstract

Work will continue on the design, synthesis, and biological testing of novel analogs of the luteinizing hormone-releasing hormone decapeptide. It is expected that peptides can be discovered which have improved and prolongedantiovulatory activities in the rat and other animal species.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
• Type: Research and Development Contracts (N01)
• Project #: N01HD042832-002
• Application #: 3651065
• Project Start: 1984-09-30
• Project End: 1986-09-29
• Budget Start: 1985-05-01
• Budget End: 1986-09-29
• Fiscal Year: 1985

Institution

• Name: Tulane University
• Type: Schools of Medicine
• City: New Orleans
• State: LA
• Country: United States
• Zip Code: 70118

Publications

Hocart, S J; Nekola, M V; Coy, D H (1988) Effect of the CH2NH and CH2NAc peptide bond isosteres on the antagonistic and histamine releasing activities of a luteinizing hormone-releasing hormone analogue. J Med Chem 31:1820-4

Hocart, S J; Nekola, M V; Coy, D H (1987) Effect of reductive alkylation of D-lysine in position 6 on the histamine-releasing activity of luteinizing hormone-releasing hormone antagonists. J Med Chem 30:739-43

Hocart, S J; Nekola, M V; Coy, D H (1987) Structure-activity studies of antagonists of luteinizing hormone-releasing hormone with emphasis on the amino-terminal region. J Med Chem 30:735-9

Hocart, S J; Nekola, M V; Coy, D H (1987) Effect of reductive alkylation of lysine in positions 6 and/or 8 on the histamine-releasing activity of luteinizing hormone-releasing hormone antagonists. J Med Chem 30:1910-4

Hocart, S J; Nekola, M V; Coy, D H (1985) Improved antagonists of luteinizing hormone-releasing hormone modified in position 7. J Med Chem 28:967-70