This project is a follow-on to a clinical trial for the """"""""Management of Hyperbilirubinemia in the Newborn"""""""". The original objective of the clinical trial was to test inhibitors of heme oxygenase (HO) to moderate hyperbilirubinemia in preterm infants, thereby reducing or eliminating the need for phototherapy and exchange transfusions. This follow-on will determine the safe, effective dose(s) of Sn-mesoporphyrin (SnNP), as well as the appropriate time(s), when this HO inhibitor should be given to be most effective clinically. The follow-on will also determine, in term infants with jaundice from a variety of causes, whether SnMP can control the subsequent rate of increase of plasma bilirubin concentration to the extent that the need for phototherapy is obviated.

Project Start
1995-08-01
Project End
2000-06-30
Budget Start
1999-08-09
Budget End
1999-06-30
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065