The purpose of this project is to assess the long-range physiological and psychological development of offspring of diabetic mothers whose pregnancies have been monitored prospectively in regard to carbohydrate, lipid, and amino acid metabolism. The reason for initiating a longitudinal follow-up of infants of carefully documented diabetic pregnancies causes significant permanent deviations from normal physiological and psychological development. The goal of the study is to discern possible functional impairments in childhood engendered by metabolic deviations from normal in utero. The organ systems of primary concern are the pancreatic islets, the central nervous system, and the musculo-skeletal system. The function of these systems will be studied in a population of offspring of diabetic mothers of sufficient sample size to demonstrate significant differences from a group of control subjects (matched for maternal age, parity, method of delivery, socioeconomic status, parental education, and ethnicity).

Project Start
1985-12-02
Project End
1990-12-01
Budget Start
1988-01-11
Budget End
1988-12-02
Support Year
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611