Abstract

The objectives of this contract are 1) to design and synthesize LHRH antagonists with reduced histamine releasing properties and 2) to define the receptor-bound conformation for antagonists by NMR studies and to use this information to design more active and longer-acting antagonists.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research and Development Contracts (N01)
Project #
N01HD062937-001
Application #
3652353
Study Section
Project Start
1986-09-30
Project End
1988-09-29
Budget Start
1987-02-26
Budget End
1988-09-29
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Tian, Z; Edwards, P; Roeske, R W (1992) Synthesis of optically pure C alpha-methyl-arginine. Int J Pept Protein Res 40:119-26
Tian, Z P; Roeske, R W (1991) Guanidination of a peptide side chain amino group on a solid support. Int J Pept Protein Res 37:425-9