The objectives of this contract are to design, synthesize LHRH antagonists with low (or no) histamine releasing properties and high antagonist potency utilizing data obtained from NMR and binding affinity studies as well as computer simulation techniques.
| Perrin, M H; Haas, Y; Porter, J et al. (1989) The gonadotropin-releasing hormone pituitary receptor interacts with a guanosine triphosphate-binding protein: differential effects of guanyl nucleotides on agonist and antagonist binding. Endocrinology 124:798-804 |
