The objectives of this project are to develop new orally active nonsteroidal agents for control of fertility in the male. It is proposed to synthesize and test a series of new indinopyridine analogs based on the lead compound- Sandoz 20-438 in order to develop a structure activity relationship directed toward enhancing the anti-spermatogenic activity and eliminating untoward pharmacological activities.
Fail, P A; Anderson, S A; Cook, C E (2000) 28-day toxicology test: indenopyridine RTI 4587-056 in male Sprague-Dawley rats. Reprod Toxicol 14:265-74 |
Cook, C E; Wani, M C; Jump, J M et al. (1995) Structure-activity studies of 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception. J Med Chem 38:753-63 |