Previous epidemiologic and genetic segregation studies of families from southern Louisiana have suggested that in a subset of families a susceptibility allele may exist that acts in conjunction with environmental risk factors (notably smoking) to increase the risk of lung cancer. An existing rapid-surveillance system in 24 southern Louisiana parishes is being used to ascertain recently diagnosed lung cancer patients. Family history and environmental risk factor data are being collected 1) on all patients and 2) on the spouses, first- and second- degree relatives and half-sibs of patients with at least 2 affected relatives. Blood samples and other biological samples (such as formalin- fixed or snap-frozen tissue blocks) are also being collected from 15-20 of these families with at least 2 affected relatives in addition to the initial patient, based on whether the family is likely to be informative for linkage analysis. A set of approximately 10 families ascertained during previous preliminary studies in this population are also being extended and additional biological samples collected to increase the value of these families for linkage analysis. Histopathological confirmation is also being collected on all affected individuals in these 25-30 pedigrees. These data and biological samples will be provided to NIH investigators to be used to search the genome for linkage to a lung cancer susceptibility locus in a timely and efficient manner.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research and Development Contracts (N01)
Project #
N01HG065404-003
Application #
2866129
Study Section
Project Start
1996-09-30
Project End
2000-09-29
Budget Start
1998-08-21
Budget End
1999-09-29
Support Year
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Liu, Yanhong; Kheradmand, Farrah; Davis, Caleb F et al. (2016) Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. J Thorac Oncol 11:52-61
Xiong, Donghai; Wang, Yian; Kupert, Elena et al. (2015) A recurrent mutation in PARK2 is associated with familial lung cancer. Am J Hum Genet 96:301-8
Liu, Pengyuan; Yang, Ping; Wu, Xifeng et al. (2010) A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. Cancer Res 70:3128-35
You, Ming; Wang, Daolong; Liu, Pengyuan et al. (2009) Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clin Cancer Res 15:2666-74
Liu, Pengyuan; Vikis, Haris G; Wang, Daolong et al. (2008) Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst 100:1326-30
Mandal, Diptasri M; Sorant, Alexa J M; Atwood, Larry D et al. (2006) Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment. BMC Genet 7:21