Abstract

The overall objective of the multi-center study, """"""""Clinical Centers For The Study of Pediatric Lung and Heart Complications of Human Immunodeficiency Virus (HIV) Infection"""""""" is to determine the natural history and epidemiology of pediatric cardiopulmonary complications of HIV infection. In responding to RFP No. NHLBI-HR-88-09, The Children's Hospital, boston City Hospital, Brigham and Women""""""""s Hospital and Beth Israel Hospital of Boston, Massachusetts propose to work cooperatively with other centers under contract with NHLBI, to accomplish these objectives as outlined below. The primary objectives of the program are: 1. To collect information on the prenatal course and the subsequent pulmonary and cardiac structure, growth, and function of infants and children with vertically transmitted HIV infection. 2. To determine the types, incidence, course, and outcome of pulmonary and cardiovascular disorders in these children and to elucidate the etiology and pathophysiology of these lung and heart abnormalities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Lung Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR096041-013
Application #
2317479
Study Section
Project Start
1989-05-22
Project End
1997-07-31
Budget Start
1994-06-13
Budget End
1996-04-06
Support Year
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Cox, Gerald F; Sleeper, Lynn A; Lowe, April M et al. (2006) Factors associated with establishing a causal diagnosis for children with cardiomyopathy. Pediatrics 118:1519-31
Towbin, Jeffrey A; Lowe, April M; Colan, Steven D et al. (2006) Incidence, causes, and outcomes of dilated cardiomyopathy in children. JAMA 296:1867-76
Fisher, Stacy D; Easley, Kirk A; Orav, E John et al. (2005) Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 150:439-47
Geromanos, Kimberly; Sunkle, Susan N; Mauer, Mary Beth et al. (2004) Successful techniques for retaining a cohort of infants and children born to HIV-infected women: the prospective P2C2 HIV study. J Assoc Nurses AIDS Care 15:48-57
Perez-Atayde, A R; Kearney, D I; Bricker, J T et al. (2004) Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study. Pediatr Dev Pathol 7:61-70
Koumbourlis, Anastassios C; Chen, Xin C; Rao, J Sunil et al. (2004) Maximal expiratory flow at FRC (V'maxFRC): Methods of selection and differences in reported values. Pediatr Pulmonol 37:318-23
Kearney, Debra L; Perez-Atayde, Antonio R; Easley, Kirk A et al. (2003) Postmortem cardiomegaly and echocardiographic measurements of left ventricular size and function in children infected with the human immunodeficiency virus. The Prospective P2C2 HIV Multicenter Study. Cardiovasc Pathol 12:140-8
Rivenes, Shannon M; Colan, Steven D; Easley, Kirk A et al. (2003) Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study. Am Heart J 145:716-23
Lipshultz, Steven E; Easley, Kirk A; Orav, E John et al. (2002) Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study. Lancet 360:368-73
Starc, Thomas J; Lipshultz, Steven E; Easley, Kirk A et al. (2002) Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV study. J Pediatr 141:327-34

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