The overall objective of the Feasibility of Retinoic Acid Treatment in Emphysema (FORTE) study is to conduct preliminary studies at 5 clinical centers preparatory to conducting a randomized, controlled, clinical trial on the efficacy of retinoic acid therapy in the management of emphysema. Objectives are to identify optimal patient populations, drugs and dosing schedules, and outcome measures for a large study, if indicated. This project serves as the Data Coordinating Center which will collect, verify, store, and analyze data from the Clinical Centers.

Agency
National Institute of Health (NIH)
Institute
Division of Lung Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR096140-001
Application #
6286792
Study Section
Project Start
1999-09-30
Project End
2002-09-29
Budget Start
2000-03-20
Budget End
2000-07-31
Support Year
Fiscal Year
2000
Total Cost
$149,131
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
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Muindi, Josephia R; Roth, Michael D; Wise, Robert A et al. (2008) Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients. J Clin Pharmacol 48:96-107
Roth, Michael D; Connett, John E; D'Armiento, Jeanine M et al. (2006) Feasibility of retinoids for the treatment of emphysema study. Chest 130:1334-45
Guo, Xu; Pan, Wei; Connett, John E et al. (2005) Small-sample performance of the robust score test and its modifications in generalized estimating equations. Stat Med 24:3479-95