Abstract

The overall objective of the Feasibility of Retinoic Acid Treatment in Emphysema (FORTE) study is to conduct preliminary studies at 5 clinical centers preparatory to conducting a randomized, controlled, clinical trial on the efficacy of retinoic acid therapy in the management of emphysema. Objectives are to identify optimal patient populations, drugs and dosing schedules, and outcome measures for a large study, if indicated. This project serves as a clinical center for the study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Lung Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HR096141-000
Application #
6191633
Study Section
Project Start
1999-09-30
Project End
2002-09-29
Budget Start
1999-09-30
Budget End
2000-03-31
Support Year
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Boston University
Department
Type
Organized Research Units
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

D'Armiento, Jeanine M; Scharf, Steven M; Roth, Michael D et al. (2009) Eosinophil and T cell markers predict functional decline in COPD patients. Respir Res 10:113
Muindi, Josephia R; Roth, Michael D; Wise, Robert A et al. (2008) Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients. J Clin Pharmacol 48:96-107
Roth, Michael D; Connett, John E; D'Armiento, Jeanine M et al. (2006) Feasibility of retinoids for the treatment of emphysema study. Chest 130:1334-45