The overall objective of this program is to support the testing of integrated implantable electrically powered ventricular assist systems (VAS) to establish clinical readiness. The objectives of this program include the in vitro and in vivo testing in animals of a tether-free implantable system consisting of an electrically actuated energy converter and a blood pump that can support the failing ventricle which is unresponsive to medical or surgical therapy. It includes the demonstration of acceptable system performance, reliability, and host response to the system. The effort specifically includes test protocol development, VAS and test equipment fabrication, VAS performance and reliability testing, VAS in vivo testing, cadaver studies, and the preparation of reports and technical data.
| Rintoul, T C; Moise, J C; Butler, K C et al. (1990) An intrathoracic left ventricular assist system: utilization of results from a development program. ASAIO Trans 36:M392-5 |
| Moritz, A; Fujimoto, L K; Wollenek, G et al. (1989) Sustained heart failure induced by repeated microsphere injections for left ventricular assist device testing. ASAIO Trans 35:455-8 |
| Moritz, A; Fujimoto, L K; Oku, T et al. (1987) Experimental model for LVAS evaluation under unphysiologic conditions. ASAIO Trans 33:689-94 |
| Moise, J; Butler, K; Payne, J et al. (1985) Experimental evaluation of complete electrically powered ventricular assist system. Trans Am Soc Artif Intern Organs 31:202-5 |
