The primary objective of this multi-center project is to stimulate innovation in implantable ventricular assist systems that are designed to achieve at least a five-year lifetime. It is anticipated that the proposed systems will incorporate the latest advances in our understanding of circulatory support requirements, including physiology, materials science, physics and bioengineering, biocompatibility, tissue engineering, In situ tissue renewal, quality control, and manufacturing.

National Institute of Health (NIH)
Division of Heart And Vascular Diseases (NHLBI)
Research and Development Contracts (N01)
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Nimbus, Inc.
Rancho Cordova
United States
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Fukamachi, Kiyotaka (2004) New technologies for mechanical circulatory support: current status and future prospects of CorAide and MagScrew technologies. J Artif Organs 7:45-57
Doi, Kazuyoshi; Golding, Leonard A R; Massiello, Alex L et al. (2004) Preclinical readiness testing of the Arrow International CorAide left ventricular assist system. Ann Thorac Surg 77:2103-10
Snyder, Trevor A; Watach, Mary J; Litwak, Kenneth N et al. (2002) Platelet activation, aggregation, and life span in calves implanted with axial flow ventricular assist devices. Ann Thorac Surg 73:1933-8
Fukamachi, Kiyotaka; Ochiai, Yoshie; Doi, Kazuyoshi et al. (2002) Chronic evaluation of the Cleveland Clinic CorAide left ventricular assist system in calves. Artif Organs 26:529-33
Ochiai, Yoshie; Golding, Leonard A R; Massiello, Alex L et al. (2002) Cleveland clinic CorAide blood pump circulatory support without anticoagulation. ASAIO J 48:249-52
Ochiai, Y; Golding, L A; Massiello, A L et al. (2001) In vivo hemodynamic performance of the Cleveland Clinic CorAide blood pump in calves. Ann Thorac Surg 72:747-52
Wagner, W R; Schaub, R D; Sorensen, E N et al. (2000) Blood biocompatibility analysis in the setting of ventricular assist devices. J Biomater Sci Polym Ed 11:1239-59
Butler, K C; Dow, J J; Litwak, P et al. (1999) Development of the Nimbus/University of Pittsburgh innovative ventricular assist system. Ann Thorac Surg 68:790-4
Baker, L C; Kameneva, M V; Watach, M J et al. (1998) Assessment of bovine platelet life span with biotinylation and flow cytometry. Artif Organs 22:799-803
Baker, L C; Davis, W C; Autieri, J et al. (1998) Flow cytometric assays to detect platelet activation and aggregation in device-implanted calves. J Biomed Mater Res 41:312-21

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