Abstract

The primary objective of this multi-center project is to stimulate innovation in implantable ventricular assist systems that are designed to achieve at least a five-year lifetime. It is anticipated that the proposed systems will incorporate the latest advances in our understanding of circulatory support requirements, including physiology, materials science, physics and bioengineering, biocompatibility, tissue engineering, in situ tissue renewal, quality control, and manufacturing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Heart And Vascular Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HV058156-009
Application #
6348673
Study Section
Project Start
1995-09-30
Project End
2001-09-29
Budget Start
2000-09-06
Budget End
2001-09-29
Support Year
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Surgery
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Yamanaka, Hanako; Rosenberg, Gerson; Weiss, William J et al. (2006) Short-term in vivo studies of surface thrombosis in a left ventricular assist system. ASAIO J 52:257-65
Yamanaka, Hanako; Rosenberg, Gerson; Weiss, William J et al. (2005) Multiscale analysis of surface thrombosis in vivo in a left ventricular assist system. ASAIO J 51:567-77
Xu, Ruijian; Manias, Evangelos; Snyder, Alan J et al. (2003) Low permeability biomedical polyurethane nanocomposites. J Biomed Mater Res A 64:114-9
Liu, Q; Runt, J; Felder, G et al. (2000) In vivo and in vitro stability of modified poly(urethaneurea) blood sacs. J Biomater Appl 14:349-66
Wu, L; Weisberg, D M; Runt, J et al. (1999) An investigation of the in vivo stability of poly(ether urethaneurea) blood sacs. J Biomed Mater Res 44:371-80