Abstract

The purpose of this program is to assess whether hormonal replacement therapy and/or antioxidant treatment will stabilize or inhibit progression, and induce regression of coronary plaques in women. Phase 1(8 months) comprises planning and organizing the Study Protocols, Manual of Operations, and data forms. Protocol Development will take approximately 6 months. After Protocol Development, there will be an approximate 2 month hiatus in activity on the study. During this time, the participating centers will prepare and submit revised cost proposals based on the actual protocol. Phase 11(4 years) will be for patient recruitment and patient follow-up. Phase 111(6 months) is for data analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Heart And Vascular Diseases (NHLBI)
Type
Research and Development Contracts (N01)
Project #
N01HV068170-006
Application #
6313757
Study Section
Project Start
1996-08-30
Project End
2002-05-31
Budget Start
2000-05-09
Budget End
2001-04-30
Support Year
Fiscal Year
2000
Total Cost
$362,897
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Williams, Marlene S; Vaidya, Dhananjay; Kickler, Thomas et al. (2005) Long-term hormone replacement therapy does not cause increased platelet activation. Am Heart J 150:434-8
Kelemen, Mark; Vaidya, Dhananjay; Waters, David D et al. (2005) Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: a substudy of the Women's Angiographic Vitamin and Estrogen (WAVE) trial. Atherosclerosis 179:193-200
Bittner, Vera; Tripputi, Mark; Hsia, Judith et al. (2004) Remnant-like lipoproteins, hormone therapy, and angiographic and clinical outcomes: the Women's Angiographic Vitamin & Estrogen Trial. Am Heart J 148:293-9
Levy, Andrew P; Friedenberg, Paula; Lotan, Rachel et al. (2004) The effect of vitamin therapy on the progression of coronary artery atherosclerosis varies by haptoglobin type in postmenopausal women. Diabetes Care 27:925-30
Hsia, Judith; Bittner, Vera; Tripputi, Mark et al. (2003) Metabolic syndrome and coronary angiographic disease progression: the Women's Angiographic Vitamin & Estrogen trial. Am Heart J 146:439-45
Waters, David D; Alderman, Edwin L; Hsia, Judith et al. (2002) Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial. JAMA 288:2432-40
Hsia, Judith; Alderman, Edwin L; Verter, Joel I et al. (2002) Women's angiographic vitamin and estrogen trial: design and methods. Control Clin Trials 23:708-27