The objective of this contract is to perform research leading to the development of a miniature tether-free electromechanically actuated implantable cardiac replacement system. An implantable cardiac replacement system as defined here includes biventricular support which assist the right and left ventricles which remain in situ and the total artificial heart which replaces the excised natural heart. The implantable subsystems of the replacement system include right and left heart blood pumps, and electromechanical energy converter(s), appropriate control systems, and implantable battery pack to provide short-term energy source for the system, a variable volume device and a mechanism for delivering electrical energy for outside to inside the body. The external battery pack will include electrochemical batteries, charging circuitry, and system monitor/diagnostic circuitry.

National Institute of Health (NIH)
Division of Heart And Vascular Diseases (NHLBI)
Research and Development Contracts (N01)
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Cleveland Clinic Lerner
United States
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Kamohara, Keiji; Weber, Stephan; Klatte, Ryan S et al. (2007) Hemodynamic and metabolic changes during exercise in calves with total artificial hearts of different sizes yet similar output. Artif Organs 31:667-76
Fukamachi, K; McCarthy, P M; Vargo, R et al. (1996) Anatomic fitting studies of a total artificial heart in heart transplant recipients. Critical dimensions and prediction of fit. ASAIO J 42:M337-42
Fukamachi, K; Benavides, M E; Wika, K E et al. (1995) Assessment of circulating blood volume in calves with a total artificial heart. ASAIO J 41:M262-5
McCarthy, P M; Fukamachi, K; Fukumura, F et al. (1994) The Cleveland Clinic-Nimbus total artificial heart. In vivo hemodynamic performance in calves and preclinical studies. J Thorac Cardiovasc Surg 108:420-8
Harasaki, H; Fukamachi, K; Massiello, A et al. (1994) Progress in Cleveland Clinic-Nimbus total artificial heart development. ASAIO J 40:M494-8
Massiello, A; Kiraly, R; Butler, K et al. (1994) The Cleveland Clinic-Nimbus total artificial heart. Design and in vitro function. J Thorac Cardiovasc Surg 108:412-9
Fukamachi, K; Massiello, A L; Kiraly, R J et al. (1993) Effects of a total artificial heart right stroke volume limiter on left-right hemodynamic balance. ASAIO J 39:M410-4
Fukamachi, K; Fukumura, F; Kiraly, R J et al. (1993) Hemodynamic changes with posture in calves with total artificial heart. ASAIO J 39:M419-22
Rintoul, T C; Butler, K C; Thomas, D C et al. (1993) Continuing development of the Cleveland Clinic-Nimbus total artificial heart. ASAIO J 39:M168-71
Irie, H; Massiello, A; Kiraly, R et al. (1992) Initial in vivo tests of an electrohydraulic actuated total artificial heart. ASAIO J 38:M497-500

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