The specific objectives of this contract are to establish the validity of current documentation of observed early initial response treatment of acute ischemic stroke with recombinant tissue plasminogen activator (rt- PA) and to establish time limits for delivering such treatment. The objectives will be accomplished by completing a Phase II-B randomized controlled clinical study of rt-PA for acute ischemic stroke.

Project Start
1990-06-30
Project End
1993-06-29
Budget Start
1991-02-06
Budget End
1992-06-29
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Neurosciences
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Rhoney, Denise H; Coplin, William M; Lin, Yan et al. (2010) Time of day, outcome, and response to thrombolytic therapy: the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Trial experience. J Stroke Cerebrovasc Dis 19:40-8
Nichols, Christopher; Khoury, Jane; Brott, Thomas et al. (2008) Intravenous recombinant tissue plasminogen activator improves arterial recanalization rates and reduces infarct volumes in patients with hyperdense artery sign on baseline computed tomography. J Stroke Cerebrovasc Dis 17:64-8
Jauch, Edward C; Lindsell, Christopher; Broderick, Joseph et al. (2006) Association of serial biochemical markers with acute ischemic stroke: the National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study. Stroke 37:2508-13
Tanne, David; Macko, Richard F; Lin, Yan et al. (2006) Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic stroke. Stroke 37:1798-804
National Institute of Neurological Disorders Stroke rt-PA Stroke Study Group (2005) Recombinant tissue plasminogen activator for minor strokes: the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study experience. Ann Emerg Med 46:243-52
Kwiatkowski, Thomas; Libman, Richard; Tilley, Barbara C et al. (2005) The impact of imbalances in baseline stroke severity on outcome in the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study. Ann Emerg Med 45:377-84
Lu, Mei; Lyden, Patrick D; Brott, Thomas G et al. (2005) Beyond subgroup analysis: improving the clinical interpretation of treatment effects in stroke research. J Neurosci Methods 143:209-16
Hacke, Werner; Donnan, Geoffrey; Fieschi, Cesare et al. (2004) Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 363:768-74
Tanne, D; Levine, S R; Brey, R L et al. (2003) Antiphospholipid-protein antibodies and acute ischemic stroke in the NINDS rt-PA Stroke Trial. Neurology 61:1158-9
Bruno, A; Levine, S R; Frankel, M R et al. (2002) Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. Neurology 59:669-74

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