Abstract

The specific objective of this contract is to determine the optimal frequency for performing magnetic resonance imaging in untreated multiple sclerosis patients. The Contractor shall demonstrate that the recommended frequency of imaging will minimize missing important changes that may occur, avoid duplication of studies, and permit monitoring of disease activity, and quantification of progression in an expeditious and cost- effective manner.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research and Development Contracts (N01)
Project #
N01NS002397-002
Application #
2321447
Study Section
Project Start
1990-09-30
Project End
1992-09-29
Budget Start
1991-06-18
Budget End
1992-09-29
Support Year
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Meier, D S; Balashov, K E; Healy, B et al. (2010) Seasonal prevalence of MS disease activity. Neurology 75:799-806
Prat, Alexandre; Biernacki, Katarzyna; Saroli, Tanya et al. (2005) Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability. Arch Neurol 62:795-800
Goldberg-Zimring, Daniel; Achiron, Anat; Guttmann, Charles R G et al. (2003) Three-dimensional analysis of the geometry of individual multiple sclerosis lesions: detection of shape changes over time using spherical harmonics. J Magn Reson Imaging 18:291-301
Sperling, R A; Guttmann, C R; Hohol, M J et al. (2001) Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch Neurol 58:115-21
Weiner, H L; Guttmann, C R; Khoury, S J et al. (2000) Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage. J Neuroimmunol 104:164-73
Khoury, S J; Guttmann, C R; Orav, E J et al. (2000) Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch Neurol 57:1183-9
Gerig, G; Welti, D; Guttmann, C R et al. (2000) Exploring the discrimination power of the time domain for segmentation and characterization of active lesions in serial MR data. Med Image Anal 4:31-42
Khoury, S J; Orav, E J; Guttmann, C R et al. (1999) Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis. Neurology 53:758-64
Guttmann, C R; Kikinis, R; Anderson, M C et al. (1999) Quantitative follow-up of patients with multiple sclerosis using MRI: reproducibility. J Magn Reson Imaging 9:509-18
Kikinis, R; Guttmann, C R; Metcalf, D et al. (1999) Quantitative follow-up of patients with multiple sclerosis using MRI: technical aspects. J Magn Reson Imaging 9:519-30

Showing the most recent 10 out of 14 publications